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T-LYMPHOCYTES, CYTOTOXIC
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DeCS
Descriptor
English
:
T-Lymphocytes, Cytotoxic
Descriptor
Spanish
:
Linfocitos T Citotóxicos
Descriptor
Portuguese
:
Linfócitos T Citotóxicos
Synonyms
English
:
Cell-Mediated Lympholytic Cells
Cytotoxic T-Lymphocytes
TC1 Cells
TC2 Cells
Tree Number:
A11.118.637.555.283.875
A11.118.637.555.567.550.500.200
A11.118.637.555.567.569.220.200
A11.118.637.555.567.569.500.200
A15.145.229.637.555.283.875
A15.145.229.637.555.567.550.500.200
A15.145.229.637.555.567.569.220.200
A15.145.229.637.555.567.569.500.200
A15.382.490.555.283.875
A15.382.490.555.567.550.500.200
A15.382.490.555.567.569.220.200
A15.382.490.555.567.569.500.200
Definition
English
:
Immunized
T-lymphocytes
which can directly destroy appropriate target cells. These cytotoxic
lymphocytes
may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after
immunization
with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and
NATURAL KILLER T-CELLS
. There are two effector phenotypes: TC1 and TC2.
Indexing Annotation
English
:
if subpopulations are discussed, coordinate IM with
T-LYMPHOCYTE SUBSETS
(IM)
History Note
English
:
90; was T LYMPHOCYTES, CYTOTOXIC 1983-89
Allowable Qualifiers
English
:
CH
chemistry
CL
classification
CY
cytology
DE
drug effects
EN
enzymology
IM
immunology
ME
metabolism
MI
microbiology
PS
parasitology
PA
pathology
PH
physiology
RE
radiation effects
RA
radiography
RI
radionuclide imaging
SE
secretion
TR
transplantation
US
ultrasonography
UL
ultrastructure
VI
virology
Record Number:
23531
Unique Identifier:
D013602
Occurrence in VHL
:
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CID-10
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